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We present here an agnostic investigation of genetic determinants of circulating AAT levels in a general population sample by performing a genome-wide association studyGWASin 1392 individuals of the SAPALDIA cohort.

Information which has been imported from another database using automatic procedures.

It should be noted that whilein theorytwo different sequences could have the same checksum valuethe likelihood that this would happen is extremely low.

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nonetheless, the finding of a higher evolutionary rate in serpina2 ancestral branch aa2 and the evidence for several amino acid substitutions being evolving under positive selection, support the hypothesis of the emergence of a new advantageous function after duplication.

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