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The use of Prograf in liver transplant recipients experiencing post-transplant hepatic impairment may be associated with increased risk of developing renal insufficiency related to high whole-blood concentrations of tacrolimusThese patients should be monitored closely and dosage adjustments should be consideredSome evidence suggests that lower doses should be used in these patientssee Dosage In Adult KidneyLiverOr Heart Transplant PatientsUse in Specific Populations and CLINICAL PHARMACOLOGY

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Change in your mental stateproblems with speech or walkingdecreased visionmay start gradually and get worse quickly

Avoid eating grapefruit or drinking grapefruit juice while being treated with this medication unless your doctor instructs you otherwiseGrapefruit can increase the amount of certain medications in your bloodstreamConsult your doctor or pharmacist for more details.

Increased risk for developing serious infections and malignancies with PROGRAF or other immunosuppressants that may lead to hospitalization or deathsee WARNINGS AND PRECAUTIONS

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